Roman
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John
So different from the other three in chronology, idiom and content that harmonising is not an option. Two endings, and a famous passage the earliest manuscripts do not have.
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Luke
A formal preface, a two-volume work with Acts, and a census in chapter 2 that remains a real and unresolved historical difficulty.
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Mark
The shortest Gospel, earliest on the majority view, and the book with the most important textual fact in the New Testament attached to its final page.
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Matthew
Jewish framing, five discourses, fulfilment formulas — and a dating argument that turns on a single verse about a burnt city.